Article
Prevalence of resistance-associated substitutions to NS3, NS5A and NS5B inhibitors at DAA-failure in hepatitis C virus in Italy from 2015 to 2019.
Le infezioni in medicina - 1 Jun 2021
Rossetti Barbara, Paglicci Lorenzo, Di Maio Velia C, Cassol Chiara, Barbaliscia Silvia, Paolucci Stefania, Bruzzone Bianca, Coppola Nicola, Montagnani Francesca, Micheli Valeria, Monno Laura, Zanelli Giacomo, Santantonio Teresa, Cuomo Nunzia, Caudai Cinzia, Zazzi Maurizio, Ceccherini-Silberstein Francesca, On Behalf Of The Hcv Virology Italian Resistance Network Vironet C
Abstract excerpt
Despite the high efficacy of direct-acting antivirals (DAAs), the selection of resistance-associated substitutions (RASs) after virological failure of hepatitis C virus (HCV) DAAs can impair the cure of chronic HCV. The aim of the study was to characterize RASs after virological failure of DAAs in Italy over the years. Within the Italian network VIRONET-C, the change in prevalence of NS3/4A-NS5A-NS5B RASs was...
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