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Clinical, radiological and molecular characterization of intramedullary astrocytomas

8 Aug 2020

Abstract excerpt

Intramedullary astrocytomas (IMAs) are rare tumors, and few studies specific to the molecular alterations of IMAs have been performed. Recently, KIAA1549-BRAF fusions and the H3F3A p.K27M mutation have been described in low-grade (LG) and high-grade (HG) IMAs, respectively. In the present study, we collected clinico-radiological data and performed targeted next-generation sequencing for 61 IMAs (26 grade I...

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PMID: 32771057
DOI: 10.1186/s40478-020-00962-1

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