Article
Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans.
Nature communications - 7 Aug 2020
Wen Gui-Ping, He Linling, Tang Zi-Min, Wang Si-Ling, Zhang Xu, Chen Yuan-Zhi, Lin Xiaohe, Liu Chang, Chen Jia-Xin, Ying Dong, Chen Zi-Hao, Wang Ying-Bin, Luo Wen-Xin, Huang Shou-Jie, Li Shao-Wei, Zhang Jun, Zheng Zi-Zheng, Zhu Jiang, Xia Ning-Shao
Abstract excerpt
Efficacy evaluation through human trials is crucial for advancing a vaccine candidate to clinics. Next-generation sequencing (NGS) can be used to quantify B cell repertoire response and trace antibody lineages during vaccination. Here, we demonstrate this application with a case study of Hecolin®, the licensed vaccine for hepatitis E virus (HEV). Four subjects are administered the vaccine following a standard...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.