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Prognostic impact of TP53 mutation, monosomal karyotype, and prior myeloid disorder in nonremission acute myeloid leukemia at allo-HSCT.

Bone marrow transplantation - 1 Feb 2021

Najima Yuho, Sadato Daichi, Harada Yuka, Oboki Keisuke, Hirama Chizuko, Toya Takashi, Doki Noriko, Haraguchi Kyoko, Yoshifuji Kota, Akiyama Megumi, Inamoto Kyoko, Igarashi Aiko, Kobayashi Takeshi, Kakihana Kazuhiko, Okuyama Yoshiki, Sakamaki Hisashi, Harada Hironori, Ohashi Kazuteru

Abstract excerpt

Outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in nonremission acute myeloid leukemia (AML) are dismal [2-year overall survival (OS): 20-30%]. Though several risk classifications have been used, some factors are unavailable until the start of conditioning or transplantation. We analyzed prognostic gene mutations by targeted next-generation sequencing to identify predisposing factors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32760007
DOI: 10.1038/s41409-020-01016-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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