Article
Remission Status Prior to Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia/Myelodysplastic Syndrome Patients Harboring Single-Hit or Multi-Hit p53 Mutations Does Not Impact Outcome.
Transplantation and cellular therapy - 1 Feb 2026
Steiner Normann, Klyuchnikov Evgeny, Badbaran Anita, Massoud Radwan, Gagelmann Nico, Rudolph Ina, Heidenreich Silke, Wolf Dominik, Zeck Gaby, Lueck Catherina, Ayuk Francis Ayuketang, Kröger Nicolaus
Abstract excerpt
Patients with TP53-mutated acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) represent a heterogeneous group and have a poor prognosis even after allogeneic stem cell transplantation (allo-SCT). This study examined the post-transplantation outcomes of patients based on their pretransplantation TP53 mutational status to assess the impact of multi-hit and single-hit mutations. A retrospective...
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