Article
Differential Behaviours and Preferential Bindings of Influenza Nucleoproteins on Importins-α.
Viruses - 30 Jul 2020
Donchet Amélie, Vassal-Stermann Emilie, Gérard Francine C A, Ruigrok Rob W H, Crépin Thibaut
Abstract excerpt
Influenza viruses are negative single-stranded RNA viruses with nuclear transcription and replication. They enter the nucleus by using the cellular importin-α/-β nuclear import machinery. Influenza nucleoproteins from influenza A, B, C and D viruses possess a nuclear localization signal (NLS) localized on an intrinsically disordered extremity (NPTAIL). In this paper, using size exclusion chromatography (SEC),...
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