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Subtyping Alzheimer's disease and Parkinson's disease using longitudinal electronic health records.

Nature aging - 1 Mar 2026

Lian Jie, Fan Zhengxian, Petrazzini Ben Omega, Fan Wei, Rao Shishir, Yang Qianqian, Zeng Guyu, Ahmed Nouman, Tabassi Mofrad Fatemeh, Wamil Malgorzata, Rahimi Kazem

Abstract excerpt

Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) are clinically heterogeneous, hampering the success of nonselective treatment strategies. Here we apply a transformer-based unsupervised clustering framework to longitudinal electronic health record data from over 100,000 patients across two UK cohorts, Clinical Practice Research Datalink Aurum and UK Biobank, to identify,...

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Identifiers

PMID: 41748957
DOI: 10.1038/s43587-026-01085-3
PMCID: PMC13004679

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