Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson.

doi:10.1038/s42003-020-01137-3

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Keratoconus-susceptibility gene identification by corneal thickness genome-wide association study and artificial intelligence IBM Watson.

Communications biology - 31 Jul 2020

Hosoda Yoshikatsu, Miyake Masahiro, Meguro Akira, Tabara Yasuharu, Iwai Sachiko, Ueda-Arakawa Naoko, Nakano Eri, Mori Yuki, Yoshikawa Munemitsu, Nakanishi Hideo, Khor Chiea-Chuen, Saw Seang-Mei, Yamada Ryo, Matsuda Fumihiko, Cheng Ching-Yu, Mizuki Nobuhisa, Tsujikawa Akitaka, Yamashiro Kenji

Abstract excerpt

Keratoconus is a common ocular disorder that causes progressive corneal thinning and is the leading indication for corneal transplantation. Central corneal thickness (CCT) is a highly heritable characteristic that is associated with keratoconus. In this two-stage genome-wide association study (GWAS) of CCT, we identified a locus for CCT, namely STON2 rs2371597 (P = 2.32 × 10-13), and confirmed a significant...

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Identifiers

PMID: 32737415
DOI: 10.1038/s42003-020-01137-3
PMCID: PMC7395727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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