Article
A risk-associated Active transcriptome phenotype expressed by histologically normal human breast tissue and linked to a pro-tumorigenic adipocyte population.
Breast cancer research : BCR - 31 Jul 2020
Kang Taekyu, Yau Christina, Wong Christopher K, Sanborn John Z, Newton Yulia, Vaske Charlie, Benz Stephen C, Krings Gregor, Camarda Roman, Henry Jill E, Stuart Josh, Powell Mark, Benz Christopher C
Abstract excerpt
BACKGROUND: Previous studies have identified and validated a risk-associated Active transcriptome phenotype commonly expressed in the cancer-adjacent and histologically normal epithelium, stroma, and adipose containing peritumor microenvironment of clinically established invasive breast cancers, conferring a 2.5- to 3-fold later risk of dying from recurrent breast cancer. Expression of this Active transcriptome...
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