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Article

Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture.

PloS one - 1 Jan 2012

Negi Sarita, Jetha Arif, Aikin Reid, Hasilo Craig, Sladek Rob, Paraskevas Steven

Abstract excerpt

The stresses encountered during islet isolation and culture may have deleterious effects on beta-cell physiology. However, the biological response of human islet cells to isolation remains poorly characterized. A better understanding of the network of signaling pathways induced by islet isolation and culturing may lead to strategies aimed at improving islet graft survival and function. Laser capture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22299040
DOI: 10.1371/journal.pone.0030415
PMCID: PMC3267725

Genes

SOX4
SOX9

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