Article
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
Stroke - 1 Feb 2012
McDonald David A, Shi Changbin, Shenkar Robert, Stockton Rebecca A, Liu Feifei, Ginsberg Mark H, Marchuk Douglas A, Awad Issam A
Abstract excerpt
BACKGROUND AND PURPOSE: Cerebral cavernous malformations (CCMs) are characterized by grossly dilated capillaries, associated with vascular leak and hemorrhage, and occur in sporadic or inherited (autosomal-dominant) forms with mutations in 1 of 3 gene loci (CCM 1, 2 or 3). We previously reported that the CCM1 protein (KRIT1) localizes to endothelial cell-cell junctions and loss of KRIT1 leads to junctional...
Topics
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Animals
- Brain
- Cerebral Hemorrhage
- Enzyme Inhibitors
- Inflammation
- Intracranial Arteriovenous Malformations
- KRIT1 Protein
- Mice
- Mice, Knockout