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Article

Distinct DNA Methylation Signatures in Neuroendocrine Tumors Specific for Primary Site and Inherited Predisposition.

The Journal of clinical endocrinology and metabolism - 1 Oct 2020

Tirosh Amit, Killian Jonathan Keith, Petersen David, Zhu Yuelin Jack, Walker Robert L, Blau Jenny E, Nilubol Naris, Patel Dhaval, Agarwal Sunita K, Weinstein Lee Scott, Meltzer Paul, Kebebew Electron

Abstract excerpt

PURPOSE: To compare the deoxyribonucleic acid (DNA) methylation signature of neuroendocrine tumors (NETs) by primary tumor site and inherited predisposition syndromes von Hippel-Lindau disease (VHL) and multiple endocrine neoplasia type 1 (MEN1). METHODS: Genome-wide DNA methylation (835 424 CpGs) of 96 NET samples. Principal components analysis (PCA) and unsupervised hierarchical clustering analyses were used to...

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Identifiers

PMID: 32706863
DOI: 10.1210/clinem/dgaa477
PMCID: PMC7456345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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