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Article

NETs: organ-related epigenetic derangements and potential clinical applications.

Oncotarget - 30 Aug 2016

Cives Mauro, Simone Valeria, Rizzo Francesca Maria, Silvestris Franco

Abstract excerpt

High-throughput next-generation sequencing methods have recently provided a detailed picture of the genetic landscape of neuroendocrine tumors (NETs), revealing recurrent mutations of chromatin-remodeling genes and little-to-no pathogenetic role for oncogenes commonly mutated in cancer. Concurrently, multiple epigenetic modifications have been described across the whole spectrum of NETs, and their putative...

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Identifiers

PMID: 27418145
DOI: 10.18632/oncotarget.10598
PMCID: PMC5302998

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