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Article

Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease: A case-control study and a meta-analysis.

Medicine - 17 Jul 2020

Chang Hsueh-Lu, Chen Guei-Rung, Hsiao Po-Jen, Chiu Chih-Chien, Tai Ming-Cheng, Kao Chung-Cheng, Tsai Dung-Jang, Su Hao, Chen Yu-Hsuan, Chen Wei-Teing, Su Sui-Lung

Abstract excerpt

BACKGROUND: Previous meta-analyses have explored the association between the C677T polymorphism of methyltetrahydrofolate reductase (MTHFR) and chronic kidney disease (CKD) but there were no studies with a decisive conclusion. Furthermore, the high heterogeneity among different populations is not yet interpreted. OBJECTIVES: This study used trial sequential analysis (TSA) to evaluate whether the nowadays...

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Identifiers

PMID: 32702845
DOI: 10.1097/MD.0000000000021045
PMCID: PMC7373545

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Source receipt: pubmed, retrieved 7 Sept 2026.

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