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Article

Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 May 2009

Jamison Rex L, Shih Mei-Chiung, Humphries Donald E, Guarino Peter D, Kaufman James S, Goldfarb David S, Warren Stuart R, Gaziano J Michael, Lavori Philip

Abstract excerpt

BACKGROUND: Abnormalities in the gene regulating methylenetetrahydrofolate reductase (MTHFR) are associated with increased homocysteine levels and increased mortality in normal and chronic kidney disease (CKD) populations. STUDY DESIGN: Gene association study. SETTING & PARTICIPANTS: This was a substudy of 677 patients from 21 Veterans Affairs medical centers participating in a randomized clinical trial...

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Source

Identifiers

PMID: 19272686
DOI: 10.1053/j.ajkd.2008.12.023

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study.PMID 19272686Read ↗

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