Article
Circulating-tumor DNA as predictor of enzalutamide response post-abiraterone treatment in metastatic castration-resistant prostate cancer.
Cancer treatment and research communications - 1 Jan 2020
Moses Marcus, Niu Alex, Lilly Michael B, Hahn Andrew W, Nussenzveig Roberto, Ledet Elisa, Manogue Charlotte, Cotogno Patrick, Lewis Brian, Layton Jodi, Agarwal Neeraj, Sartor Oliver, Barata Pedro C
Abstract excerpt
BACKGROUND: The crossover from abiraterone acetate (AA) to enzalutamide (ENZA) is a frequent approach in clinical practice. Our aim was to explore the role of genomic alterations as putative biomarkers of response to sequential AA followed by ENZA in mCRPC and their association with clinical outcomes. PATIENTS AND METHODS: This was a multi-center, retrospective analysis of mCRPC patients with circulating-tumor...
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