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Article

Family-based exome sequencing combined with linkage analyses identifies rare susceptibility variants of MUC4 for gastric cancer.

PloS one - 1 Jan 2020

Choi Yoon Jin, Ohn Jung Hun, Kim Nayoung, Kim Wonji, Park Kyungtaek, Won Sungho, Sael Lee, Shin Cheol Min, Lee Sun Min, Lee Sejoon, An Hyun Joo, Jang Dong Man, Han Byung Woo, Lee Hye Seung, Kang Seung Joo, Kim Joo Sung, Lee Dong Ho

Abstract excerpt

Genome-wide association studies of gastric cancer (GC) cases have revealed common gastric cancer susceptibility loci with low effect size. We investigated rare variants with high effect size via whole-exome sequencing (WES) of subjects with familial clustering of gastric cancer. WES of DNAs from the blood of 19 gastric cancer patients and 36 unaffected family members from 14 families with two or more gastric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32701958
DOI: 10.1371/journal.pone.0236197
PMCID: PMC7377420

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