Article
Microfluidic enrichment for the single cell analysis of circulating tumor cells.
Scientific reports - 29 Feb 2016
Yeo Trifanny, Tan Swee Jin, Lim Chew Leng, Lau Dawn Ping Xi, Chua Yong Wei, Krisna Sai Sakktee, Iyer Gopal, Tan Gek San, Lim Tony Kiat Hon, Tan Daniel S W, Lim Wan-Teck, Lim Chwee Teck
Abstract excerpt
Resistance to drug therapy is a major concern in cancer treatment. To probe clones resistant to chemotherapy, the current approach is to conduct pooled cell analysis. However, this can yield false negative outcomes, especially when we are analyzing a rare number of circulating tumor cells (CTCs) among an abundance of other cell types. Here, we develop a microfluidic device that is able to perform high throughput,...
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