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Article

NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells.

Journal of virology - 15 Sept 2020

Conde Jonas N, Schutt William R, Mladinich Megan, Sohn Sook-Young, Hearing Patrick, Mackow Erich R

Abstract excerpt

Zika virus (ZIKV) is cytopathic to neurons and persistently infects brain microvascular endothelial cells (hBMECs), which normally restrict viral access to neurons. Despite replicating in the cytoplasm, ZIKV and Dengue virus (DENV) polymerases, NS5 proteins, are predominantly trafficked to the nucleus. We found that a SUMO interaction motif in ZIKV and DENV NS5 proteins directs nuclear localization. However, ZIKV...

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Identifiers

PMID: 32699085
DOI: 10.1128/JVI.01086-20
PMCID: PMC7495392

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