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Article

Single-Cell Proteomics Reveals Novel Cell Phenotypes in Marfan Mouse Aneurysm.

Molecular & cellular proteomics : MCP - 1 Apr 2026

Saddic Louis, Dinh Ashley, Kaneda Giselle, Momenzadeh Amanda, Zilberberg Lior, Song Yang, Mastali Mitra, Kreimer Simion, Hutton Alexandre, Haghani Ali, Meyer Jesse G, Parker Sarah J

Abstract excerpt

This report describes single-cell proteomic analyses of cells dissociated from a complex mammalian tissue using direct label-free mass spectrometry (single-cell proteomics by mass spectrometry, SCP-MS). The nanoDTSC approach was applied to profile individual cells from aorta of male and female wild-type and Fbn1C1041G/+ Marfan mice. Leiden clustering identified all major aortic cell types including seven distinct...

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Identifiers

PMID: 41785993
DOI: 10.1016/j.mcpro.2026.101549
PMCID: PMC13090654

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