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Article

Single-Nucleus Multiomic Analyses Identifies Gene Regulatory Dynamics of Phenotypic Modulation in Human Aneurysmal Aortic Root.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jun 2024

Liu Xuanyu, Zeng Qingyi, Yang Hang, Li Wenke, Chen Qianlong, Yin Kunlun, Pan Zihang, Wang Kai, Luo Mingyao, Shu Chang, Zhou Zhou

Abstract excerpt

Aortic root aneurysm is a potentially life-threatening condition that may lead to aortic rupture and is often associated with genetic syndromes, such as Marfan syndrome (MFS). Although studies with MFS animal models have provided valuable insights into the pathogenesis of aortic root aneurysms, this understanding of the transcriptomic and epigenomic landscape in human aortic root tissue remains incomplete. This...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38552156
DOI: 10.1002/advs.202400444
PMCID: PMC11165511

Genes

FOXN3
ACTA2
BACH1
BACH2
TEAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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