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Article

Whole-exome sequencing in an Afrikaner family with bipolar disorder.

Journal of affective disorders - 1 Nov 2020

Engelbrecht Hannah-Ruth, Dalvie Shareefa, Agenbag Gloudi, Stein Dan J, Ramesar Raj S

Abstract excerpt

BACKGROUND: Bipolar disorder (BD) has considerable heritability, with genome-wide association studies indicating that multiple common genetic variants contribute to risk. Less work has been undertaken to assess the contribution of rare variation in the development of this complex disorder, particularly in isolated populations. Using whole-exome sequencing (WES), the aim of this study was to identify rare,...

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PMID: 32697718
DOI: 10.1016/j.jad.2020.06.045

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