Article
Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder.
Translational psychiatry - 14 Feb 2017
Lescai F, Als T D, Li Q, Nyegaard M, Andorsdottir G, Biskopstø M, Hedemand A, Fiorentino A, O'Brien N, Jarram A, Liang J, Grove J, Pallesen J, Eickhardt E, Mattheisen M, Bolund L, Demontis D, Wang A G, McQuillin A, Mors O, Wang J, Børglum A D
Abstract excerpt
Bipolar disorder affects about 1% of the world's population, and its estimated heritability is about 75%. Only few whole genome or whole-exome sequencing studies in bipolar disorder have been reported, and no rare coding variants have yet been robustly identified. The use of isolated populations might help finding variants with a recent origin, more likely to have drifted to higher frequency by chance. Following...
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