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Article

Microfluidic confinement enhances phenotype and function of hepatocyte spheroids.

American journal of physiology. Cell physiology - 1 Sept 2020

Choi Jong Hoon, Loarca Lorena, De Hoyos-Vega Jose M, Dadgar Neda, Loutherback Kevin, Shah Vijay H, Stybayeva Gulnaz, Revzin Alexander

Abstract excerpt

A number of cell culture approaches have been described for maintenance of primary hepatocytes. Forming hepatocytes into three-dimensional (3-D) spheroids is one well-accepted method for extending epithelial phenotype of these cells. Our laboratory has previously observed enhanced function of two-dimensional (2-D, monolayer) hepatocyte cultures in microfluidic devices due to increased production of several...

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Identifiers

PMID: 32697600
DOI: 10.1152/ajpcell.00094.2020
PMCID: PMC7509267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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