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Article

Photoreceptors Degenerate Through Pyroptosis After Experimental Retinal Detachment

22 Jul 2020

Abstract excerpt

Purpose: Gasdermin D (GSDMD) is crucial in neuronal pyroptosis. GSDMD-N and GSDMD-C are two subdomains of the protein GSDMD. GSDMD-N is an executor of pyroptosis, and GSDMD-C has an inhibitory effect on pyroptotic cell death. This study evaluated the role of GSDMD in photoreceptor cell pyroptosis caused by retinal detachment (RD). Methods: RD models were established in rats, and GSDMD cleavage was detected by...

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PMID: 32697303
DOI: 10.1167/iovs.61.8.31

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