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Article

Bayesian modelling of high-throughput sequencing assays with malacoda.

PLoS computational biology - 1 Jul 2020

Ghazi Andrew R, Kong Xianguo, Chen Ed S, Edelstein Leonard C, Shaw Chad A

Abstract excerpt

NGS studies have uncovered an ever-growing catalog of human variation while leaving an enormous gap between observed variation and experimental characterization of variant function. High-throughput screens powered by NGS have greatly increased the rate of variant functionalization, but the development of comprehensive statistical methods to analyze screen data has lagged. In the massively parallel reporter assay...

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PMID: 32692749
DOI: 10.1371/journal.pcbi.1007504
PMCID: PMC7394446

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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