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Article

Differing Activity Profiles of the Stereoisomers of 2,3,5,6TMP-TQS, a Putative Silent Allosteric Modulator of α7 nAChR.

Molecular pharmacology - 1 Oct 2020

Papke Roger L, Garai Sumanta, Stokes Clare, Horenstein Nicole A, Zimmerman Arthur D, Abboud Khalil A, Thakur Ganesh A

Abstract excerpt

Many synthetic compounds to which we attribute specific activities are produced as racemic mixtures of stereoisomers, and it may be that all the desired activity comes from a single enantiomer. We have previously shown this to be the case with the α7 nicotinic acetylcholine receptor positive allosteric modulator (PAM) 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide (TQS) and the...

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Identifiers

PMID: 32690627
DOI: 10.1124/mol.120.119958
PMCID: PMC7472127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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