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Article

The association of rs2233679 in the PIN1 gene promoter with the risk of Coronary Artery Disease in Chinese female individuals.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Aug 2020

Wang Jing-Zhang, Du Wen-Tao, Bai Jing, Cheng Shu-Zhen, Zhang Yu-Hua

Abstract excerpt

BACKGROUNDS: Vascular atherosclerosis leads to various cardiovascular and cerebrovascular diseases. Nitric oxide (NO) promotes vasodilatation and prevents Coronary Artery Disease (CAD). Pin1 suppresses NO production by down-regulating the activity of endothelial nitric oxide synthase (eNOS). Whether the genetic polymorphisms of the PIN1 gene (encoding Pin1) are implicated in CAD deserves investigations in human...

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Identifiers

PMID: 32689581
DOI: 10.1016/j.jstrokecerebrovasdis.2020.104935

Genes

CAD
PIN1

Provenance

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