Article
Association of APOE (rs429358 and rs7412) and PON1 (Q192R and L55M) Variants with Myocardial Infarction in the Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan.
Genes - 10 Mar 2023
Rahman Naveed, Zakiullah, Jan Asif, Saeed Muhammad, Khan Muhammad Asghar, Parveen Zahida, Iqbal Javaid, Ali Sajid, Shah Waheed Ali, Akbar Rani, Khuda Fazli
Abstract excerpt
Coronary Artery Diseases (CAD) remains the top among Non-communicable Diseases (NCDs). Variations in Apolipoprotein E (APOE) and Paroxonase 1 (PON1) have been associated with Myocardial Infarction (MI) in several populations. However, despite the high prevalence of CAD, no such study has been reported in the Pashtun ethnic population of Pakistan. We have conducted a two-stage (i.e., screening and validation)...
Topics
- Humans
- Case-Control Studies
- Pakistan
- Aryldialkylphosphatase
- Myocardial Infarction
- Polymorphism, Single Nucleotide
- Coronary Artery Disease
- Apolipoproteins E