Article
Using a phenotype microarray and transcriptome analysis to elucidate multi-drug resistance regulated by the PhoR/PhoP two-component system in Bacillus subtilis strain NCD-2.
Microbiological research - 1 Oct 2020
Guo Qinggang, Dong Lihong, Wang Peipei, Su Zhenhe, Liu Xiaomeng, Zhao Weisong, Zhang Xiaoyun, Li Shezeng, Lu Xiuyun, Ma Ping
Abstract excerpt
The PhoRP two-component system (TCS), one of the most important signaling pathways in Bacillus subtilis, regulates cell physiological reactions mainly under phosphate starvation conditions. The mechanism by which PhoRP TCS regulates resistance towards antibiotics in B. subtilis strain NCD-2 was investigated in this study. Using phenotype microarray (PM) technology, the susceptibility of B. subtilis to 240...
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