Article
A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities.
Diabetes - 1 May 2007
Prudente Sabrina, Flex Elisabetta, Morini Eleonora, Turchi Federica, Capponi Daria, De Cosmo Salvatore, Tassi Vittorio, Guida Valentina, Avogaro Angelo, Folli Franco, Maiani Francesca, Frittitta Lucia, Dallapiccola Bruno, Trischitta Vincenzo
Abstract excerpt
Aquaporin 7 (AQP7), the gateway protein controlling glycerol release, has recently emerged as a modulator of adipocyte metabolism. AQP7 knockout mice develop obesity and hyperglycemia. The contribution of AQP7 to these abnormalities in humans is unknown. We examined whether common single nucleotide polymorphisms (SNPs) in the AQP7 gene modulate the risk of obesity and related abnormalities. Among several SNPs we...
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