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Article

High-throughput microfluidic blood testing to phenotype genetically linked platelet disorders: an aid to diagnosis.

Blood advances - 24 Oct 2023

Fernandez Delia I, Provenzale Isabella, Canault Matthias, Fels Salome, Lenz Antonia, Andresen Felicia, Krümpel Anne, Dupuis Arnaud, Heemskerk Johan W M, Boeckelmann Doris, Zieger Barbara

Abstract excerpt

Linking the genetic background of patients with bleeding diathesis and altered platelet function remains challenging. We aimed to assess how a multiparameter microspot-based measurement of thrombus formation under flow can help identify patients with a platelet bleeding disorder. For this purpose...

Topics

Humans
Blood Platelet Disorders
Male
Female
Phenotype
Adult
Middle Aged
Adolescent
Child
Hematologic Tests
Young Adult
Microfluidics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Blood Platelets

Guanine Nucleotide Exchange Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 37389831
DOI: 10.1182/bloodadvances.2023009860
PMCID: PMC10582840

Genes

P2RY12
HPS3
RASGRP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-37389831-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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