Article

A humanised thrombus-on-a-chip model utilising tissue-engineered arterial constructs: A method to reduce and replace mice used in thrombosis and haemostasis research.

2025-01-20

Abstract excerpt

The study of in vivo thrombus formation has principally been performed using intravital microscopy in mice and other species. These have allowed us to visualise the molecular and cellular processes that regulate thrombus formation inside the body. However current in vivo arterial thrombosis models are difficult to standardise between labs and frequently produce results that do not reliably translate successfully...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 134749b3-3af6-5ea5-abb7-3d7e4b27227f
DOI: 10.12688/f1000research.158910.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A humanised thrombus-on-a-chip model utilising tissue-engineered arterial constructs: A method to reduce and replace mice used in thrombosis and haemostasis research.DOI 10.12688/f1000research.158910.1Read

Hormone-induced thrombosis is mediated through non-canonical fibrin(ogen) aggregation and a novel estrogen target in zebrafishSemantic proximity Read

Smart Clot: An Automated Point-of-Care Flow Assay for Quantitative Whole-Blood Platelet, Fibrin and Thrombus KineticsSemantic proximity Read

Tissue factor and thrombosis models.Semantic proximity Read

Murine models of vascular thrombosis (Eitzman series).Semantic proximity Read

Inhibiting monocyte migration reduces arterial thrombosis and facilitates thrombolysisSemantic proximity Read

Porcine testing of a novel second generation mechanical thrombectomy device to evaluate effects on arterial and venous intima and vessel integritySemantic proximity Read

Humanizing thrombi in mice.Semantic proximity Read

Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.Semantic proximity Read

Cellular, Molecular, and Enzymatic Signatures of Thrombi are Vascular Bed-DependentSemantic proximity Read

Development of in vitro cardiovascular tissue models within capillary circuit microfluidic devices fabricated with 3D Stereolithography printingSemantic proximity Read

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in miceSemantic proximity Read

Mouse models of deep vein thrombosisSemantic proximity Read