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Article

Transient Decrease of Circulating and Tissular Dendritic Cells in Patients With Mycobacterial Disease and With Partial Dominant IFNγR1 Deficiency.

Frontiers in immunology - 1 Jan 2020

Dotta Laura, Vairo Donatella, Giacomelli Mauro, Moratto Daniele, Tamassia Nicola, Vermi William, Lonardi Silvia, Casanova Jean-Laurent, Bustamante Jacinta, Giliani Silvia, Badolato Raffaele

Abstract excerpt

Interferon-γ receptor 1 (IFNγR1) deficiency is one of the inborn errors of IFN-γ immunity underlying Mendelian Susceptibility to Mycobacterial Disease (MSMD). This molecular circuit plays a crucial role in regulating the interaction between dendritic cells (DCs) and T lymphocytes, thus affecting DCs activation, maturation, and priming of T cells involved in the immune response against intracellular pathogens. We...

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Identifiers

PMID: 32676075
DOI: 10.3389/fimmu.2020.01161
PMCID: PMC7333364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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