IRF8 mutations and human dendritic-cell immunodeficiency.

doi:10.1056/NEJMoa1100066

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Article

IRF8 mutations and human dendritic-cell immunodeficiency.

The New England journal of medicine - 14 Jul 2011

Hambleton Sophie, Salem Sandra, Bustamante Jacinta, Bigley Venetia, Boisson-Dupuis Stéphanie, Azevedo Joana, Fortin Anny, Haniffa Muzlifah, Ceron-Gutierrez Lourdes, Bacon Chris M, Menon Geetha, Trouillet Céline, McDonald David, Carey Peter, Ginhoux Florent, Alsina Laia, Zumwalt Timothy J, Kong Xiao-Fei, Kumararatne Dinakantha, Butler Karina, Hubeau Marjorie, Feinberg Jacqueline, Al-Muhsen Saleh, Cant Andrew, Abel Laurent, Chaussabel Damien, Doffinger Rainer, Talesnik Eduardo, Grumach Anete, Duarte Alberto, Abarca Katia, Moraes-Vasconcelos Dewton, Burk David, Berghuis Albert, Geissmann Frédéric, Collin Matthew, Casanova Jean-Laurent, Gros Philippe

Abstract excerpt

BACKGROUND: The genetic analysis of human primary immunodeficiencies has defined the contribution of specific cell populations and molecular pathways in the host defense against infection. Disseminated infection caused by bacille Calmette-Guérin (BCG) vaccines is an early manifestation of primary immunodeficiencies, such as severe combined immunodeficiency. In many affected persons, the cause of disseminated BCG...

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PMID: 21524210
DOI: 10.1056/NEJMoa1100066
PMCID: PMC3136554

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