Phenotypic progression of a rat lymphoid cell line immortalized by human T-lymphotropic virus type I to induce lymphoma/leukemia-like disease in rats.

doi:10.1128/JVI.66.11.6686-6694.1992

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Article

Phenotypic progression of a rat lymphoid cell line immortalized by human T-lymphotropic virus type I to induce lymphoma/leukemia-like disease in rats.

Journal of virology - 1 Nov 1992

Oka T, Sonobe H, Iwata J, Kubonishi I, Satoh H, Takata M, Tanaka Y, Tateno M, Tozawa H, Mori S

Abstract excerpt

Rat lymphoid cells, TARS-1, immortalized by coculture with adult T-cell leukemia cells, were intraperitoneally injected into 65 newborn, inbred WKAH/Hkm rats. In most of the rats, tumor nodules were discernible 7 to 15 days after transplantation but were completely rejected within 5 to 6 weeks. Two rats with no tumor nodules exhibited gait disturbances and paralysis of the hind legs 3 to 4 weeks after...

Topics

Animals
Animals, Newborn
Cell Division
Cell Line, Transformed
Cell Transformation, Neoplastic
Cell Transformation, Viral
Disease Models, Animal
HTLV-I Infections
Injections, Intraperitoneal
Karyotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, T-Cell

Lymphoid Tissue

Lymphoma

Phenotype

Rats

Rats, Inbred Strains

Source

Open in PubMed Open full text

Identifiers

PMID: 1404610
DOI: 10.1128/JVI.66.11.6686-6694.1992
PMCID: PMC240164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1404610-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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