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Generation of stem cell-derived β-cells from patients with type 1 diabetes

10 May 2016

Abstract excerpt

We recently reported the scalable in vitro production of functional stem cell-derived β-cells (SC-β cells). Here we extend this approach to generate the first SC-β cells from type 1 diabetic patients (T1D). β-cells are destroyed during T1D disease progression, making it difficult to extensively study them in the past. These T1D SC-β cells express β-cell markers, respond to glucose both in vitro and in vivo,...

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PMID: 27163171
DOI: 10.1038/ncomms11463

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