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Article

Mutations in sphingolipid metabolism genes are associated with ADHD.

Translational psychiatry - 13 Jul 2020

Henriquez-Henriquez Marcela, Acosta Maria T, Martinez Ariel F, Vélez Jorge I, Lopera Francisco, Pineda David, Palacio Juan D, Quiroga Teresa, Worgall Tilla S, Deckelbaum Richard J, Mastronardi Claudio, Molina Brooke S G, Arcos-Burgos Mauricio, Muenke Maximilian

Abstract excerpt

Attention deficit hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder in children, with genetic factors accounting for 75-80% of the phenotypic variance. Recent studies have suggested that ADHD patients might present with atypical central myelination that can persist into adulthood. Given the essential role of sphingolipids in myelin formation and maintenance, we explored genetic...

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Share to Attention Deficit Disorder with Hyperactivity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Share to Sphingomyelin Phosphodiesterase

Source

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Identifiers

PMID: 32661301
DOI: 10.1038/s41398-020-00881-8
PMCID: PMC7359313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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