Article
Medullary Pancreatic Carcinoma Due to Somatic POLE Mutation: A Distinctive Pancreatic Carcinoma With Marked Long-Term Survival.
Pancreas - 1 Aug 2020
Kryklyva Valentyna, Ter Linden Esther, Kroeze Leonie I, de Voer Richarda M, van der Kolk B Marion, Stommel Martijn W J, Hermans John J, Luchini Claudio, Wood Laura D, Hruban Ralph H, Nagtegaal Iris D, Ligtenberg Marjolijn J L, Brosens Lodewijk A A
Abstract excerpt
Medullary pancreatic carcinoma (MPC) is a rare histological variant of pancreatic ductal adenocarcinoma (PDAC). Because of its rarity, data on the molecular background of MPC are limited. Previous studies have shown that a subset of MPCs is microsatellite instable due to mismatch repair deficiency. Here, we present a unique case of a female patient in her 60s who is a long-term survivor after surgery for...
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