Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-Dose Effect of MEFV Gain-of-Function Mutations Determines ex vivo Neutrophil Activation in Familial Mediterranean Fever.

Frontiers in immunology - 1 Jan 2020

Stoler Iris, Freytag Judith, Orak Banu, Unterwalder Nadine, Henning Stephan, Heim Katrin, von Bernuth Horst, Krüger Renate, Winkler Stefan, Eschenhagen Patience, Seipelt Eva, Mall Marcus A, Foell Dirk, Kessel Christoph, Wittkowski Helmut, Kallinich Tilmann

Abstract excerpt

Familial Mediterranean fever (FMF) is caused by mutations within the Mediterranean fever (MEFV) gene. Disease severity depends on genotype and gene dose with most serious clinical courses observed in patients with M694V homozygosity. Neutrophils are thought to play an important role in the initiation and perpetuation of inflammatory processes in FMF, but little is known about the specific characteristics of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase 1
Share to Familial Mediterranean Fever

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gain of Function Mutation

Share to Gene Dosage

Share to Interleukin-18

Share to Neutrophil Activation

Share to Neutrophils

Source

Open in PubMed Open full text

Identifiers

PMID: 32655537
DOI: 10.3389/fimmu.2020.00716
PMCID: PMC7325897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-Dose Effect of MEFV Gain-of-Function Mutations Determines ex vivo Neutrophil Activation in Familial Mediterranean Fever.PMID 32655537Read ↗

Correlation of Secretory Activity of Neutrophils With Genotype in Patients With Familial Mediterranean Fever.Semantic proximity Read ↗

Activated phenotype of circulating neutrophils in familial Mediterranean fever.Semantic proximity Read ↗

Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases.Semantic proximity Read ↗

Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines.Semantic proximity Read ↗

Increased NLRP3-dependent interleukin 1β secretion in patients with familial Mediterranean fever: correlation with MEFV genotype.Semantic proximity Read ↗

Cytokine-Induced Transcriptional Changes in Human Neutrophils Reveal Immune Regulatory PlasticitySemantic proximity Read ↗

Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever.Semantic proximity Read ↗

LPS-induced gene expression of inflammation-related genes in neutrophils from familial Mediterranean fever patientsSemantic proximity Read ↗

Chronic myelomonocytic leukemia as a cause of fatal uncontrolled inflammation in familial Mediterranean fever.Semantic proximity Read ↗

Transcriptional analysis of neutrophils from patients with Behçet's disease reveals activation and chemotaxis of neutrophilsSemantic proximity Read ↗

Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable.Semantic proximity Read ↗

Genetic analysis of C5a receptors in neutrophils from patients with familial Mediterranean fever.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.