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Article

Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases.

Journal of clinical immunology - 1 Jul 2021

Malengier-Devlies Bert, Metzemaekers Mieke, Gouwy Mieke, Van Nieuwenhove Erika, Betrains Albrecht, Cockx Maaike, Vanbrabant Lotte, Pörtner Noëmie, Vercauteren Jurgen, De Somer Lien, Struyf Sofie, Vanderschueren Steven, De Langhe Ellen, Proost Paul, Matthys Patrick, Wouters Carine

Abstract excerpt

PURPOSE: Familial Mediterranean Fever (FMF) and Pyrin-Associated Autoinflammation with Neutrophilic Dermatosis (PAAND) are clinically distinct autoinflammatory disorders caused by mutations in the pyrin-encoding gene MEFV. We investigated the transcriptional, phenotypical, and functional characteristics of patient neutrophils to explore their potential role in FMF and PAAND pathophysiology. METHODS: RNA...

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Identifiers

PMID: 33666778
DOI: 10.1007/s10875-021-01008-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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