Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic myelomonocytic leukemia as a cause of fatal uncontrolled inflammation in familial Mediterranean fever.

Orphanet journal of rare diseases - 16 Jun 2015

Awad Fawaz, Georgin-Lavialle Sophie, Brignier Anne, Derrieux Coralie, Aouba Achille, Stankovic-Stojanovic Katia, Grateau Gilles, Amselem Serge, Hermine Olivier, Karabina Sonia-Athina

Abstract excerpt

We report on a familial Mediterranean fever (FMF) patient homozygous for p.M694V in the MEFV gene who developed chronic myelomonocytic leukemia (CMML) leading to an uncontrolled and fatal inflammatory syndrome. Plasma levels of IL-6 and IL-18 were found to be very high, as compared to healthy controls and CMML-free FMF patients.Our study unveils the interplay between two different disorders involving the same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Familial Mediterranean Fever

Share to Inflammation

Share to Interleukin-18

Share to Interleukin-6

Share to Leukemia, Myelomonocytic, Chronic

Source

Open in PubMed Open full text

Identifiers

PMID: 26076658
DOI: 10.1186/s13023-015-0295-9
PMCID: PMC4485869

Genes

MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic myelomonocytic leukemia as a cause of fatal uncontrolled inflammation in familial Mediterranean fever.PMID 26076658Read ↗

Unresolved Issues in Familial Mediterranean Fever: Is p.R202Q MEFV Variant Potentially Pathogenetic in Unleashing Inflammation?Semantic proximity Read ↗

Presentation of familial Mediterranean fever in a heterozygous MEFV mutation triggered by immunosuppressive therapy for myelodysplastic syndrome.Semantic proximity Read ↗

Acquired familial Mediterranean fever associated with a somatic MEFV mutation in a patient with JAK2 associated post-polycythemia myelofibrosis.Semantic proximity Read ↗

Macrophage activation syndrome revealing familial Mediterranean fever.Semantic proximity Read ↗

NLRP1 inflammasome drives IL-18 in Familial Mediterranean Fever and MEFV variantsSemantic proximity Read ↗

Activated phenotype of circulating neutrophils in familial Mediterranean fever.Semantic proximity Read ↗

Enhanced cytokine mRNA levels in attack-free patients with familial Mediterranean fever.Semantic proximity Read ↗

Correlation of Secretory Activity of Neutrophils With Genotype in Patients With Familial Mediterranean Fever.Semantic proximity Read ↗

Interleukin-6 targeting therapy in familial Mediterranean fever.Semantic proximity Read ↗

R202Q/M694V as novel MEFV gene mutations in chronic periodontitis and familial Mediterranean fever.Semantic proximity Read ↗

Ex vivo PBMC cytokine profile in familial Mediterranean fever patients: Involvement of IL-1β, IL-1α and Th17-associated cytokines and decrease of Th1 and Th2 cytokinesSemantic proximity Read ↗

Evidence of digenic inheritance in autoinflammation-associated genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.