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A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis

12 Jul 2020

Abstract excerpt

Classification of acute lymphoblastic and myeloid leukemias (ALL and AML) remains heavily based on phenotypic resemblance to normal hematopoietic precursors. This framework can provide diagnostic challenges for immunophenotypically heterogeneous immature leukemias, and ignores recent advances in understanding of developmental multipotency of diverse normal hematopoietic progenitor populations that are identified...

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PMID: 32655144
DOI: 10.1038/s41375-020-0965-z

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