Article
Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.
Circulation - 11 Aug 2020
Mahmoodi Bakhtawar K, Tragante Vinicius, Kleber Marcus E, Holmes Michael V, Schmidt Amand F, McCubrey Raymond O, Howe Laurence J, Direk Kenan, Allayee Hooman, Baranova Ekaterina V, Braund Peter S, Delgado Graciela E, Eriksson Niclas, Gijsberts Crystel M, Gong Yan, Hartiala Jaana, Heydarpour Mahyar, Pasterkamp Gerard, Kotti Salma, Kuukasjärvi Pekka, Lenzini Petra A, Levin Daniel, Lyytikäinen Leo-Pekka, Muehlschlegel Jochen D, Nelson Christopher P, Nikus Kjell, Pilbrow Anna P, Wilson Tang W H, van der Laan Sander W, van Setten Jessica, Vilmundarson Ragnar O, Deanfield John, Deloukas Panos, Dudbridge Frank, James Stefan, Mordi Ify R, Teren Andrej, Bergmeijer Thomas O, Body Simon C, Bots Michiel, Burkhardt Ralph, Cooper-DeHoff Rhonda M, Cresci Sharon, Danchin Nicolas, Doughty Robert N, Grobbee Diederick E, Hagström Emil, Hazen Stanley L, Held Claes, Hoefer Imo E, Hovingh G Kees, Johnson Julie A, Kaczor Marcin P, Kähönen Mika, Klungel Olaf H, Laurikka Jari O, Lehtimäki Terho, Maitland-van der Zee Anke H, McPherson Ruth, Palmer Colin N, Kraaijeveld Adriaan O, Pepine Carl J, Sanak Marek, Sattar Naveed, Scholz Markus, Simon Tabassome, Spertus John A, Stewart Alexandre F R, Szczeklik Wojciech, Thiery Joachim, Visseren Frank L J, Waltenberger Johannes, Richards A Mark, Lang Chim C, Cameron Vicky A, Åkerblom Axel, Pare Guillaume, März Winfried, Samani Nilesh J, Hingorani Aroon D, Ten Berg Jurriën M, Wallentin Lars, Asselbergs Folkert W, Patel Riyaz S
Abstract excerpt
BACKGROUND: Studies examining the role of factor V Leiden among patients at higher risk of atherothrombotic events, such as those with established coronary heart disease (CHD), are lacking. Given that coagulation is involved in the thrombus formation stage on atherosclerotic plaque rupture, we hypothesized that factor V Leiden may be a stronger risk factor for atherothrombotic events in patients with established...
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