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Article

Prothrombin G20210A and Factor V Leiden Variants Are Not Associated With Thrombotic Events in Congenital Heart Disease: An Observational Trial.

Journal of the American Heart Association - 17 Mar 2026

Ladha Feria A, VanderPluym Christina, Mondragon-Estrada Enrique, Avillach Paul, Brueckner Martina, Chung Wendy K, Cnota James F, Gelb Bruce D, Lewis Matthew, Liu Cong, Roberts Amy E, Seidman Christine E, Tristani-Firouzi Martin, Wagner Michael, Morton Sarah U, Newburger Jane W

Abstract excerpt

BACKGROUND: Thrombotic events, including acute ischemic stroke, are more common in individuals with congenital heart disease (CHD). Whether common thrombophilia variants contribute to thrombotic risk in this population remains unclear. We evaluated whether prothrombin G20210A (F2 c.97G>A) and factor V Leiden (F5 c.1601G>A; p.Arg534Gln) are associated with thrombotic events in CHD. METHODS: Participants in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41778605
DOI: 10.1161/JAHA.125.046959
PMCID: PMC13055685

Genes

F2
F5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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