Article
Characterization of a pathogenic variant in GBA for Parkinson's disease with mild cognitive impairment patients.
Molecular brain - 8 Jul 2020
Jiang Zhiqiang, Huang Yilin, Zhang Piao, Han Chongyin, Lu Yueer, Mo Zongchao, Zhang Zhanyu, Li Xin, Zhao Sisi, Cai Fuqiang, Huang Lizhen, Chen Chunbo, Shi Zhihong, Zhang Yuhu, Ling Fei
Abstract excerpt
Parkinson's disease (PD) is the second most common neurodegenerative disease, and mild cognitive impairment (MCI) is a well-established risk factor for the development of dementia in PD. A growing body of evidence suggests that low expression of glucocerebrosidase (GBA) promotes the transmission of α-synuclein (α-Syn) interpolymers and the progression of PD. However, how GBA mutations affect the pathogenesis of...
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