Comprehensive mismatch repair gene panel identifies variants in patients with Lynch‐like syndrome

Abstract excerpt

BACKGROUND: Lynch-like syndrome (LLS) represents around 50% of the patients fulfilling the Amsterdam Criteria II/revised Bethesda Guidelines, characterized by a strong family history of Lynch Syndrome (LS) associated cancer, where a causative variant was not identified during genetic testing for LS. METHODS: Using data extracted from a larger gene panel, we have analyzed next-generation sequencing data from 22...

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• BRCA gene mutations in cancer
• Genetic factors in colorectal cancer
• Genomics and Rare Diseases