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Article

MicroRNA‑34a inhibits the proliferation and promotes the chemosensitivity of retinoblastoma cells by downregulating Notch1 expression

15 Jun 2020

Abstract excerpt

MicroRNAs (miRs) are potential therapeutic targets for tumors. The aims of the present study were to investigate the regulatory effects of miR‑34a on the proliferation, apoptosis and chemosensitivity of retinoblastoma (RB) cells, and to identify the possible underlying mechanism involving Notch1. It was found that miR‑34a was downregulated, and Notch1 was upregulated in HXO‑RB44 and Y79 cells. In addition, Notch1...

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PMID: 32626991
DOI: 10.3892/mmr.2020.11238

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