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Article

<i>MIR34A</i>regulates autophagy and apoptosis by targeting<i>HMGB1</i>in the retinoblastoma cell

3 Jan 2014

Abstract excerpt

MIR34A (microRNA 34a) is a tumor suppressor gene, but how it regulates chemotherapy response and resistance is not completely understood. Here, we show that the microRNA MIR34A-dependent high mobility group box 1 (HMGB1) downregulation inhibits autophagy and enhances chemotherapy-induced apoptosis in the retinoblastoma cell. HMGB1 is a multifaceted protein with a key role in autophagy, a self-degradative,...

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PMID: 24418846
DOI: 10.4161/auto.27418

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<i>MIR34A</i>regulates autophagy and apoptosis by targeting<i>HMGB1</i>in the retinoblastoma cellPMID 24418846Read ↗

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