Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically programmed changes in transcription of the novel progranulin regulator.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2020

Keller Maria, Gebhardt Claudia, Huth Sandra, Schleinitz Dorit, Heyne Henrike, Scholz Markus, Stumvoll Michael, Böttcher Yvonne, Tönjes Anke, Kovacs Peter

Abstract excerpt

Progranulin is a glycoprotein marking chronic inflammation in obesity and type 2 diabetes. Previous studies suggested PSRC1 (proline and serine rich coiled-coil 1) to be a target of genetic variants associated with serum progranulin levels. We aimed to identify potentially functional variants and characterize their role in regulation of PSRC1. Phylogenetic module complexity analysis (PMCA) prioritized four...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genes, Reporter

Share to Progranulins

Share to RNA, Messenger

Share to Transcription, Genetic

Share to YY1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 32620998
DOI: 10.1007/s00109-020-01942-7
PMCID: PMC7399677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Genetically programmed changes in transcription of the novel progranulin regulator.PMID 32620998Read ↗

Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin.Semantic proximity Read ↗

Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children.Semantic proximity Read ↗

The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger.Semantic proximity Read ↗

Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities).Semantic proximity Read ↗

Integrating plasma protein-centric multi-omics to identify potential therapeutic targets for pancreatic cancer.Semantic proximity Read ↗

Alterations of DNA methylation profile in peripheral blood of children with simple obesitySemantic proximity Read ↗

Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics.Semantic proximity Read ↗

Identification of genetic biomarkers of blood cholesterol levels using whole gene pathogenicity modelling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.